منابع مشابه
Ouabain and serum sodium.
Ouabain and Serum Sodium To the Editor: Sodium-dependent mechanisms play a role in the pathogenesis of hypertension. He et al recently demonstrated that in normotensive and hypertensive subjects an acute reduction in salt intake, from 350 to 10 mmol/d for 5 days, was associated with a decline in serum sodium by 3 mmol/L. Conversely, a progressive increase in salt intake from 10 to 250 mmol/d by...
متن کاملSodium pumps: ouabain, ion transport, and signaling in hypertension.
TO THE EDITOR: A recent Editorial Focus in this journal (7) addresses the newly recognized role of the sodium pump as both an ion transport protein and a hormone receptor with its own signaling cascade. The relative importance of the cardiotonic steroids (CTS) as endogenous signaling hormones versus their ability to inhibit the sodium pump is of great interest. Indeed, the article noted that “a...
متن کاملNatriuretic Hormones, Endogenous Ouabain, and Related Sodium Transport Inhibitors
The work of deWardener and colleagues stimulated longstanding interest in natriuretic hormones (NHs). In addition to the atrial peptides (APs), the circulation contains unidentified physiologically relevant NHs. One NH is controlled by the central nervous system (CNS) and likely secreted by the pituitary. Its circulating activity is modulated by salt intake and the prevailing sodium concentrati...
متن کاملOuabain and insulin induce sodium pump endocytosis in renal epithelium.
Cardiotonic steroids signaling through the basolateral sodium pump (Na/K-ATPase) have been shown to alter renal salt handling in intact animals. Because the relationship between renal salt handling and blood pressure is a key determinant of hypertension, and patients with insulin resistance are frequently hypertensive, we chose to examine whether there might be competition for resources necessa...
متن کاملEffect of Sodium Valproate on Ouabain-Induced Arrhythmia in Isolated Guinea-Pig Atria
Sodium valproate (SV), an antiepileptic drug has several mechanism of action. It inhibits voltage sensitive Na+ channels and reduces intracellular Na accumulation. These actions are similar to that of both phenytoin and carbamazepine. We have investigated the direct cardiac action of SV and its effects on ouabain-induced arrhythmia in isolated guinea-pig atria. The guinea-pig atrium was dissect...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2005
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.0000168322.39681.80